Blasting results are influenced by lots of factors,grey correlation analysis can determine the primary or secondary relationship of each factor which will affect the results of blasting.This paper verified with grey correlation analysis method that the blastability index of rock is the main fac tor affecting the blasting fragmentation of Huidong Lead-Zinc Mine and also demo nstrated that the adjustment of explosive factor and pattern parameters in blast design is still very important to the control of blasting fragmentation.