In this paper,the mechanism of maintenance and stability control of surrounding rock of coal roadway influenced by multiple mining activities under complicated condition is discussed.The technical approach of supporting and maintaining coal roadway under the influence of secondary mining and high stress is put forward,it is to apply pressure-relief principle into the maintenance and supporting of surrounding rock of coal roadway,integrally support coal roadway using pre-stressed anchor with high strength and reinforce the key parts of coal roadway.This approach has been applied into the practical engineering at some mine,and good results have been obtained.