The paper proposes a method to automatically generate three-dimensional finite element mesh for the calculation of slope reinforced by anti-sliding pile by isoparametric mapping,This method takes into account the detail mesh partition of anti-slide pile supporting structure and the boundary of pile and soil/pile,and use zero-thickness contact elements to subdivide and simulate the boundary.A slope example subdivided by mesh is calculated and analyzed with strength reduction finite element(FEM) method,and the result of FEM calculation is compared with one of calculation with limit equilibrium method.The results show that the digitized modeling by computer technology can effectively speed the pre-processing of finite element calculation and improve its quality,the suggested methods of mesh partition and calculation are reasonable and feasible.