In filling of deep mine,the key problem of filling system is the abrasion of transportation pipes but is not the blockage of transportation pipes,especially the protection of the filling drill is very important.This paper analyzes some problems presenting in pipeline transportation of backfill in deep mine,combined with the characteristics of filling system for deep mine,puts forward three optimization approaches,i.e.,multi-step layout pattern of transportation pipe,the diameter optimization of horizontal transportation pipe and vertical transportation pipe,and the makeup optimization of backfill drill.