According to the characteristics of slimy wulfenite with high limonite content from Guizhou,the flotation experiment of the wulfenite was carried out by means of sulphidizaiton-xanthate flotation method.The experimental results showed that the wulfenite can be effectively floated in sulphidizing process,the addition of sodium hexametaphosphate can improve the dispersion of the pulp,isomer-amyl xanthahte used as the collector has the well effect for the flotation of wulfenite.The addition of kerosene can enhance the surface hydrophobicity of wulfenite,heating flotation can greatly improve the effect of sulphidization and the index of flotation.The industrial examination was carried out,the molybdenum content of the concentrate was up to 5.8% and the recovery of molybdenum was up to 76% at a feed ore containing 0.67% molybdenum.