With regard to actual situation of the optimization of mine ventilation system, a mine ventilation optimization decision support system has been developed by use of object-oriented programming language Delphi and database technology, in which the basic information database of mine ventilation system has been established. The basic information database not only provides data support for model calculation, but also provides the effective way of information management of ventilation safety for safety administrator, and according to the need of ventilation safety management the various report forms have been developed. In addition, such models as multi-goal decision method, fuzzy synthesis judgment method, hierarchy process method, systems analysis method, airflow adjustment calculation, the optimizations of ventilating laneway's section and wind pressure have been established. The uses of these models make the optimization of mine ventilation system sample and easy. Consequently, the mine ventilation optimization decision support system can provide aided decision support for the optimization of mine ventilation system, and as the result the efficiency, quality and scientific decision-making level of the optimization are improved.