The one side of some hillside limestone quarry is high bedded rock slope, so the stability of this slope is a primary problem of mine safety, and the earthquake effect caused by blasting is one of great factors influencing slope stability. According to the testing and analysis of deep-hole blasting vibration effect at this mine, the influencing laws of different lithology and layer's strike on the spread of seismic wave caused by blasting were obtained, and a basis was given for forecasting earthquake caused by blasting and the blasting design of reduced vibration effect.