Strata stress increases with the increasing of mining depth, resulting in a remarkable rise of the supporting cost of drift. Therefore, it is important to study on the optimization of deep drift layout under high stress conditions. In the light of the practices of mining works in Jinchuan No.2 mine area, this paper adopts numerical simulation and similar material simulation experiment to research the optimal layout of sublevel drifts under deep high-stress conditions. The results have shown that the influences of mining on the sublevel drifts and the stress conditions of surrounding rock of the sublevel drifts is improved if the sublevel drifts are placed in the hanging rock of the draw raises, and this is advantageous to the stability of sublevel drifts.