In this paper, the theory of gray system is adopted to study the time series prediction of the leaching rate of in-situ blasting and leaching ore. According to the dynamic characteristics of in-situ leaching process and combined with the practical engineering of a certain uranium mine, the GM(1,1) models of equal dimension new signal and equal dimension successive gray data compensation are established respectively for the short-term and long-term time prediction of the leaching rate of in-situ blasting and leaching ore in the mine, and the short-term and long-term time prediction of the leaching rate of the example mine are carried out, the maximum relative errors of predicted values of this two models are 4.4% and 10%. The prediction results show that the adopted approach is reasonable and prediction accuracy is reliable.