The paper discusses the characteristics of the refractory sulfur-bearing ore, the innovative and highly selective AP series copper capturing agent and the results of various closed circuit tests of various flowcharts. It is shown that the best process for treating such ore is regrinding of coarse tailings. It is suggested that the AP-5540 can be used together with butyl xanthate as capturing agent. Lime, S-9349 and water glass can be used as inhibitors. The butyl xanthate can be used as capturing agent when de-sulfuring the copper tailings and the BK-201 can be used as foaming agent.