During the pipeline transportation of tailings slurry from the beneficiation plant to the filling preparation station, changing the feeding parameters will cause changes in the spatial distribution of tailings solid particles in the pipeline, thereby affecting the safety and stability of slurry pipeline transportation. The study focuses on the transportation of sulfide tailings from a tin ore beneficiation plant in Yunnan to the filling preparation station through pipelines. The rheological parameters of the tailings slurry were obtained through rheological tests. ANSYS FLUENT numerical simulation software was used to simulate and analyze the pipeline transportation of tailings slurry. The relationship between the relative height of the bottom bed layer and the feeding parameters was fitted, and a three-dimensional relationship model between the relative height of the bottom bed layer, feeding speed, and volume concentration was established. The results show that: ① The three-dimensional relationship model between the relative height of the bottom bed and the feed rate and volume concentration has a good fitting effect; ② Most of the coarser particles with a size of +120 mesh (125 μm) have sedimentation phenomenon in the bottom bed layer. Fine particles with a size of 120 and 200 mesh (100 μm) have sedimentation phenomenon at the bottom of the pipeline when the feeding speed is 1 m/s. They are distributed in the carrier layer when the feeding speed is above 2 m/s. Fine particles with a size of -200 mesh (75 μm) are all distributed in the carrier layer; ③ There is water in the boundary layer of the top wall of the pipeline, as well as a slurry formed by some extremely fine particles and water, which together form the boundary layer; ④ The radial volume concentration variation of tailings slurry can be divided into four regions. Among them, there is a gradient decreasing effect in region a, region b gradually increases to stability, region c reaches its maximum value and remains stable, and region d gradually decreases.