In order to determine the reasonable Space-time relationship of opposite mining in close distance coal seams, taking the 1503 working face and 11002 transportation trough as the engineering background, theoretical analysis and numerical simulation are used to analyze the distribution law of the advance abutment pressure of the working face in the process of the opposite mining and the evolution law of the floor stress of the goaf in the process of the backward mining. The theoretical calculation shows that the sum of the influence range of the advance abutment pressure of the 1503 working face and 11002 transportation trough in the opposite mining process is 131.01m, and the lag influence distance of the 1503 working face is 59.55m. The numerical simulation results show that the minimum advance influence distance between the 1503 working face and the 11002 transportation trough in the opposite mining process is 140m, and the minimum lag influence distance between the 1503 working face in the backward mining process is 60m. The theoretical calculation is basically consistent with the numerical simulation results. According to the results, a reasonable space-time relationship between 1503 working face and 11002 transportation trough is proposed to guide the safe production of the face.