In order to study the surface morphology evolution characteristics and hydraulic flow characteristics of single rough fracture under high temperature and high pressure, single fracture seepage experiment of temperature cycle was carried out under different stress and osmotic pressure conditions. The surface evolution characteristics of fracture after rising and cooling were described by three-dimensional topography scanning technology. Its influence on the seepage characteristics of single fracture granite was analyzed. After the seepage action of high temperature and high pressure, the local body of the fractured surface of the single fractured granite destroyed, and the height of the contour decreases, the fracture surface contour becomes smoother; Under different triaxial pressures, the hydraulic fracture aperture and permeability coefficient drops first and then increase with the increase of temperature, with the decrease of temperature, the hydraulic fracture aperture and permeability coefficient at the same temperature are higher than those at the heating stage; The hydraulic fracture aperture and seepage coefficient increased with the decreased of the overall roughness of the fracture surface, which is subjected to the irreversible thermal destruction of the action of high temperature and high pressure seepage.