The in-situ leaching process is usually used to exploit ionic-absorbed rare earth mine, which makes the shear strength of mines reduce, resulting in slope instability. Therefore, laboratory test was employed in this research in order to study the change rule of shear strength indices of ore body on condition that initial dry density, initial water content and pore solution type were considered. The results indicated that when the initial water content was constant, the cohesion of ionic-absorbed rare earth mine was positively correlated with the initial dry density, and its internal friction angle changed little with the initial dry density. When the initial dry density was constant, the cohesion of ionic-absorbed rare earth mine was negatively related with the initial water content, and its internal friction angle increases slightly with the increase of the initial water content. Under the influence of different initial dry density and water content, a linear relationship between Ccu and C' was good. When the initial dry density and water content were constant, the relationship between C and φ values of CU test, UU test and quick direct shear test was: Cq > Cuu > Ccu and φcu ≈ φq. When (NH4)2SO4 solution, MgSO4 solution and equal proportion mixed solution of (NH4)2SO4 and MgSO4 were used respectively as pore solution, the relationship among Cuu values of ore body: MgSO4 > (NH4)2SO4 > mixtures. In addition, the Cuu and Cq values of the ore body were almost the same when MgSO4 was used as pore solution, the Cuu and Cq values of the ore body are close to the same. The research results could provide a theoretical guidance for the stability evaluation of mine slope in the mining process of no ammonia nitrogen or less ammonia nitrogen.