It is an entirely new concept to combine the optimization of operating parameters with the a nalysis of input-output and then study them, aiming at to integrate the production, operation and management of enterprise into a whole system from the aspect of system engineering and comprehensively analyze its operating activities for technological economy so achieve best operating results. The mathematical models of operating parameters are established, and a model of synthetical technological economy analysis for a metal mine is established, based on these, the rational economic grade and marginal grade for a certain gold mine are calculated by use of the techniques of double-grade indexes asynchronous rolling and multi-purpose fuzzy synthetical assessment, finally, the grade of ore is took as a variable to build up physical-financial and dynamic input-output optimization model, the best operating parameters are obtained.