In Tonglushan Copper-Iron Mine, according to the case of the mine development system, the two main fans are installed in the underground return airways at two ends of ore deposit,thus forming a ventilation system which takes multi shafts located in the middle of both hanging and bottom walls of ore deposit as the air inlet shafts,and exhausts contaminated air and presses air to the outlet air shafts diagonally at the two ends of ore deposits.For level ventilation network,parallel doubles drifts and upwards and downwards ventilation pattern at two sides of ore deposit have be applied. The ventilation system, which has enforced exhausting and dust removal, offers good distribution of air flow to all levels and stopes, effectively controls the series accumulation of polluted air in various levels, thus reduces structures for air control.