With the emphasis on the selection of explosives, micro-exploder type and its structural parameters and safty performance, the out-body breaking effects of gallstone example, the action process of micro-exploder blasting and pressure distribution of produced shock wave, and the quantitative composition of blast reaction products, a series of explosion tests and observation were performed in the light of gallstone characteristic and existing conditions in human dile duct system and in view of the requriements of clinical practice. Based on the test results, a series of clinical practice was conducted with micro-explosion to break gallstones in bile duct system (bile duct in liver, choledochus and gallbladder included) , thus solving the theoretical and application problems of micro-explosion technique for breaking gallstone in hurman bile duct system for the first time and providing a new effective means for the treatment of human gallstone disease.