The lead - zinc ore in southwest China contains 14.28% zn and 0.44% pb. In order to improve the processing capacity of the plant , adopted the process of " dense medium-flotation combination". The results show that, 1~13mm raw ore can discard the tailings containing 39.38% yield, 0.97% zn and 0.061% pb after preconcentration by dense medium. It obtained that the final concentrate with Zn grade of 58.53%, Zn recovery rate of 94.68%, Pb grade of 1.65% , Pb recovery rate of 83.95% , Ag grade of 220.88g/t, Ag recovery rate 91.52% by heavy medium separation concentrate and 0~1mm raw ore combined with grinding and flotation.