The study focuses on the finely ground and deeply selected tailings of fine-grained iron concentrate provided by a factory in the Panxi region. The TiO2 grade is 19.51%, and the main gangue minerals are pyroxene, chlorite, and amphibole. Based on the characteristics of the ore, BY series inhibitors have been developed. The results showed that using MOH as the collector and BY-3 as the inhibitor, through a closed-loop process of "one coarse, one fine desulfurization one coarse, one sweep four fine, and returning the intermediate ore in sequence for titanium selection", a titanium concentrate yield of 30.98%, a TiO2 grade of 46.94%, a recovery rate of 74.54%, and a flotation tailings TiO2 grade of 5.27% could be obtained. The research results of this paper can provide technical references for efficient recovery and utilization of similar ores.