To further improve the application effect of curtain grouting technology in the underground near ore bodies of large water metal mines, the grouting and water plugging scheme and the grouting process should be optimized in conjunction with the actual mine, and comprehensive analysis should be made according to the mine"s situation and one mine"s policy. Summarizing the practice of underground water treatment project in the East Maanshan ore body of Anqing copper mine, the optimization plan of zoning treatment + local near ore body curtain grouting technology is proposed for the complex hydrogeological conditions, uneven development of karst and strong water-rich permeability in the area. The analysis of the geology, water influx, and borehole data has been established to identify the degree of fissure development in the study area; to determine the bad structure pattern and water-rich spatial distribution, optimize the slurry plugging parameters, and form the optimization plan of near ore body curtain with the technical idea of , inspection borehole comparison, etc. The study shows that: the curtain grouting scheme of the East Maanshan ore body from -580 to -820m in the middle section with partial near ore body has reduced the annual water influx by 36.5%, and the curtain grouting has been effective in reducing water, which has solved the threat of sudden water in the mine and achieved greater benefits for the mine, and can provide a reference for similar engineering practice.