In order to study the resistance characteristics of paste slurry in pipeline transportation, a set of small-scale loop pipe test device was designed and developed independently, which can be used to carry out loop pipe test of paste slurry under the conditions of different flow velocity, mass concentration and average particle size. The grey correlation method is used to analyze the influence of various factors on pipeline transportation resistance. The results show that the pipeline transportation resistance is the most sensitive to the mass concentration of paste slurry and increases exponentially. The flow velocity of paste slurry has the second greatest effect on pipeline transportation resistance, and the pipeline transportation resistance increases linearly with flow velocity. The average particle size of paste slurry has a dual effect on the pipeline transportation resistance, and the pipeline transportation resistance decreases at first and then increases with the increase of the average particle size. The research results provide theoretical support for the rational design and optimal layout of paste filling conveying system.