With the aim to solve the serious quality problems of cemented river sand filling mass in Xinqiao Pyrite Mine,a series of orthogonal laboratory tests on the uniaxial compressive strength of cemented river sand filling mass were carried out.By the multiple regression analysis made on the results of tests,the regression relationship of compressive strength to the concentration of slurry,the dosage of cement,the particle size of river sand,curing time and temperature was established.It was found that the main factor influencing the compressive strength of filling mass is the particle size of river sand.The results of studies provide basis for improving the quality of filling mass and reducing the filling cost.